Mouse Gene Ggps1 (ENSMUST00000170957.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
| Description: Mus musculus geranylgeranyl diphosphate synthase 1 (Ggps1), transcript variant 5, mRNA. (from RefSeq NM_010282) Gencode Transcript: ENSMUST00000170957.2 Gencode Gene: ENSMUSG00000021302.10 Transcript (Including UTRs) Position:mm10 chr13:14,050,659-14,063,488Size:12,830Total Exon Count:4Strand:- Coding Region Position:mm10 chr13:14,053,694-14,057,865Size:4,172Coding Exon Count:3
|
Comments and Description Text from UniProtKB
| ID: GGPPS_MOUSE DESCRIPTION: RecName: Full=Geranylgeranyl pyrophosphate synthase; Short=GGPP synthase; Short=GGPPSase; EC=2.5.1.-; AltName: Full=(2E,6E)-farnesyl diphosphate synthase; AltName: Full=Dimethylallyltranstransferase; EC=2.5.1.1; AltName: Full=Farnesyl diphosphate synthase; AltName: Full=Farnesyltranstransferase; EC=2.5.1.29; AltName: Full=Geranylgeranyl diphosphate synthase; AltName: Full=Geranyltranstransferase; EC=2.5.1.10; FUNCTION: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate. CATALYTIC ACTIVITY: (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. COFACTOR: Binds 3 magnesium ions per subunit (By similarity). PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. PATHWAY: Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. SUBUNIT: hom*ohexamer; trimer of hom*odimers (By similarity). SUBCELLULAR LOCATION: Cytoplasm (Potential). SIMILARITY: Belongs to the FPP/GGPP synthase family. |
Primer design for this transcript
Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3 |
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
|
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have. | |||||||||||||||||||||||
Protein Domain and Structure Information
| InterPro Domains: Graphical view of domain structure IPR000092 - Polyprenyl_synt IPR017446 - Polyprenyl_synth-rel IPR008949 - Terpenoid_synth Pfam Domains: SCOP Domains: ModBase Predicted Comparative 3D Structure on Q9WTN0
|
Orthologous Genes in Other Species
| Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene. |
Gene Ontology (GO) Annotations with Structured Vocabulary
| Molecular Function: GO:0004161 dimethylallyltranstransferase activity GO:0004311 farnesyltranstransferase activity GO:0004337 geranyltranstransferase activity GO:0016740 transferase activity GO:0042802 identical protein binding GO:0046872 metal ion binding Biological Process: Cellular Component: |
Descriptions from all associated GenBank mRNAs
| BC006798 - Mus musculus geranylgeranyl diphosphate synthase 1, mRNA (cDNA clone MGC:11417 IMAGE:2651229), complete cds. AK020659 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530089B04 product:hypothetical protein, full insert sequence. AK138564 - Mus musculus adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330064P13 product:geranylgeranyl diphosphate synthase 1, full insert sequence. AK046876 - Mus musculus 10 days neonate medulla oblongata cDNA, RIKEN full-length enriched library, clone:B830044A11 product:unclassifiable, full insert sequence. AK163652 - Mus musculus 10 days neonate medulla oblongata cDNA, RIKEN full-length enriched library, clone:B830016E06 product:geranylgeranyl diphosphate synthase 1, full insert sequence. AK138802 - Mus musculus 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430077F03 product:geranylgeranyl diphosphate synthase 1, full insert sequence. AK011980 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610304H04 product:geranylgeranyl diphosphate synthase 1, full insert sequence. BC069913 - Mus musculus geranylgeranyl diphosphate synthase 1, mRNA (cDNA clone MGC:78165 IMAGE:6469191), complete cds. AB016044 - Mus musculus mRNA for GGPP synthase, complete cds. AK132907 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930507P03 product:geranylgeranyl diphosphate synthase 1, full insert sequence. BC055884 - Mus musculus cDNA clone IMAGE:3667170, partial cds. AK089026 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430036I18 product:unclassifiable, full insert sequence. AK007605 - Mus musculus 10 day old male pancreas cDNA, RIKEN full-length enriched library, clone:1810026C22 product:RIKEN cDNA 1810026C22 gene, full insert sequence. |
Biochemical and Signaling Pathways
| KEGG - Kyoto Encyclopedia of Genes and Genomes mmu00900 - Terpenoid backbone biosynthesis mmu01100 - Metabolic pathways BioCyc Knowledge Library Reactome (by CSHL, EBI, and GO) Protein Q9WTN0 (Reactome details) participates in the following event(s): R-MMU-191303 Another isopentenyl pyrophosphate is added to geranyl pyrophosphate |
| Alternate Gene Symbols: GGPPS_MOUSE, NM_010282, Q9WTN0, uc007pmw.1, uc007pmw.2, uc007pmw.3 UCSC ID: uc007pmw.3 RefSeq Accession: NM_010282 Protein: Q9WTN0 (aka GGPPS_MOUSE or GGPP_MOUSE) CCDS: CCDS26248.1 |
